Stakeholders who do not support the trial are part of the community even though they are against what might be happening in the community, for that reason they need to be involved. Those stakeholders can be involved by using stakeholders who are involved and have much impact in the community and they have ways to approach those stakeholders.
This is very important because myths and misconceptions are usually spread by those people who do not understand, accept or support the trial. Involving them is part of managing issues and the GPP Blueprint for Stakeholders does emphasize that research teams develop an effective plan for engaging with a “full range of stakeholders” throughout the course of a biomedical HIV prevention trials.