Hi Pat,
MTN 017 is indeed a great example of how partnerships with civil society, policy makers and other stakeholders influenced pre-protocol design.
MTN 020 (ASPIRE)–the vaginal ring study– is also a good illustration of how protocols can be designed to accommodate new information as the trial progresses.
I think these ideas about ensuring early stakeholder input are also extremely relevant and applicable to all of the PrEP demo studies that are and will be ramping up…
