In my case, as a CAB member, I try to provide as much feedback as possible when consulted about the protocol; in turn, the research team fowards those feedbacks to the network level. For instance, our CAB has already identified a procotol flaw in HPTN 083 which may hamper the participation of transgender women – here in Brazil, a lot of them make use of gluteal prosthesis; but the protocol establishes that the injections have to be applied in that region, which of course will make a lot of them ineligible.