[Kathrine]

Haoyu’s comments accurately capture the formative research activities we have conducted and also the issues with them.   I was also interested in Sherri’s question to Phumeza — how far in advance are these formative research activities useful  — what are the pros and cons of doing it too early?  I feel we did this early, and created an expectation that the trial was coming soon, even though we were clear it would be 1+ year away (and now it has been 2-3 years).  As a result I feel  concerned about ensuring that we don’t move too early. For that reason, I feel like more general education around research literacy would be good as an interim step.